Strategy:Big Gun Types
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General
'Big Guns' generally refer to the BFG 9000 and weapons that can be assembled from a BFG and a few mods.
For the most part, the BFG has no weaknesses: It has all the wonderful properties of explosive weapons - massive damage and area - but its accuracy is perfect (that is, it will always explode at your chosen target unless it collides with an enemy first) and it can't harm you.
It does have one problem: It takes a lot of cells to fire a BFG and it will still destroy items and walls. If you're fully loaded then neither of these things will particularly matter to you unless you hit an invincibility globe like a dummy or something.
The BFG is great with bulk mods. One BFG shot will rarely be enough to completely solve whatever terrible situation you've found yourself in, but 3 will! Also, the BFG is commonly used as a power cell storage device (because an inventory slot can hold 50 cells... or it can hold a BFG which can hold 100) when it isn't being used as a gun - bulk mods will make it better at that.
Due to the way that BFGs can't spawn before the mid-late game, a character can't really specialise with BFGs. They are always useful as a backup weapon unless you are very reliant on a plasma rifle and need all of your power cells feeding in to the rifle.